独特的神经机制在中脑注意力网络中的抑制核中构建经典与非经典的抑制环境
Hannah M Schryver1,2, Shreesh P Mysore3,4,5
1Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, 21218, USA.
Nature communications
|June 9, 2023
概括
静脉中阻断性神经元 (Imc) 控制注意力. 经典的周围是从光学纹体 (OT) 继承的,而非经典的周围则是在Imc本身内构建的.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 感官系统 感官系统
背景情况:
- 静脉半径巨细胞体 (Imc) 是一个中脑核,对空间注意力至关重要.
- Imc 抑制神经元通过光学段 (OT) 调节刺激选择.
- 了解Imc受体场 (RF) 抑制环境的结构是理解Imc功能的关键.
研究的目的:
- 研究Imc RFs的经典和非经典抑制环境的形成背后的机制.
- 确定空间注意力电路中的这些抑制环境的起源.
主要方法:
- 利用焦点,可逆阻断GABAergic输入到Imc神经元.
- 在Imc和OT中使用配对记录和离子泳.
- 在Imc内部以及Imc和OT之间空间对齐和遥远的站点对中检查神经活动.
主要成果:
- 阻断GABAergic输入到Imc神经元,取消了非经典的抑制环境,但保留了经典的环境.
- Imc RFs的经典抑制环境起源于OT.
- 超古典的IMC RFs的抑制环境是在Imc中构建的.
结论:
- 经典的抑制环境是从光学层遗传的.
- 超古典的抑制环境是通过Imc.内部的局部计算生成的.
- 在IMC内部的竞争互动对于其在空间注意力方面的作用至关重要.
相关概念视频
Brainstem: Control Centers of Medulla
1.7K
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
1.7K
Diencephalon: Anatomical Regions
2.2K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
2.2K
Diencephalon: Thalamus and Information Relay
1.7K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.7K
Brainstem
2.3K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
2.3K
Functional Brain Systems: Reticular Formation
2.1K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.1K
Indirect Motor Pathways
1.6K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.6K


