南极地区寒冷适应的基因组学,不包括类鱼的辐射辐射
Iliana Bista1,2,3,4, Jonathan M D Wood5, Thomas Desvignes6
1Wellcome Sanger Institute, Tree of Life, Wellcome Genome Campus, Hinxton, CB10 1SA, UK. ilianabista@gmail.com.
Nature communications
|June 9, 2023
概括
南大洋的类鱼类进化了独特的适应性,如抗蛋白和血红蛋白的损失. 基因组分析揭示了它们的辐射发作以及可移植元素在塑造这些关键基因家族中的作用.
科学领域:
- * 进化生物学 进化生物学
- * 基因组学 是一个学科.
- * * 海洋生物学 海洋生物学
背景情况:
- * Notothenioids是南大洋中占主导地位的鱼类,表现出了显著的适应结温度.
- *了解它们的进化历史对于理解极地海洋生态系统至关重要.
研究的目的:
- *生成和分析24个notothenioid物种的基因组组合,以了解它们的进化辐射.
- *重建参与适应的关键基因家族,特别是抗糖蛋白和血红蛋白.
主要方法:
- *生成和分析24个新的基因组组合,包括5个长时间读取组合.
- *使用全基因组序列数据构建时间校准的基因组.
- *使用长时间读取数据重建抗糖蛋白和血红蛋白基因家族.
主要成果:
- * 估计notothenioid辐射的开始是在1070万年前.
- *鉴定出基因组大小的两倍变化,这是由可移植元素扩张驱动的.
- * 提供了抗糖蛋白基因家族最完整的重建,显示了位点扩张.
- *通过完整的集群重建,详细说明了冰鱼中功能性血红蛋白基因的丧失.
结论:
- *可移植元素扩展可能在抗和血红蛋白基因家族的进化中发挥了重要作用.
- *这项研究提供了一个全面的基因组框架,以了解notothenioid进化和适应极端环境.
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