在水生动物中,Brachyury基因的进化历史涉及重复,分歧和新功能化
Alexandra A Vetrova1, Daria M Kupaeva2, Alena Kizenko3
1Laboratory of Morphogenesis Evolution, Koltzov Institute of Developmental Biology RAS, Vavilova 26, Moscow, 119334, Russia.
Scientific reports
|June 9, 2023
概括
在类动物中,Brachyury基因进化揭示了重复和新功能化. 布拉基尤里1和2在口腔极形成了模式,而布拉基尤里3在神经细胞中多样化,这表明了水生动物中的新角色.
科学领域:
- 发育生物学 发展生物学
- 进化遗传学 进化遗传学
- 海洋生物学 海洋生物学
背景情况:
- 布拉基尤里 (Brachyury) 是一个T-box基因,对双边体中中皮层的特异性至关重要.
- 在类动物中,Brachyury基因有助于轴向模式系统.
- 了解非双边生物中的Brachyury进化为我们提供了关于动物早期发育的见解.
研究的目的:
- 为了对Cnidaria中的Brachyury基因进行基因基因分析.
- 为了研究Dynamena pumila中的Brachyury对应物的差异表达和功能.
- 在水生动物中探索Brachyury基因的进化轨迹和功能分歧.
主要方法:
- 在Cnidaria中对Brachyury基因家族进行了系遗传学分析.
- 在Dynamena pumila的差异基因表达研究.
- 药理学调制试验用于评估基因调节 (例如cWnt信号传递).
主要成果:
- 鉴定了两种Brachyury基因复制事件在cnidarian血统,导致三种副本在hydrozoans.
- 布拉基乌里1和布拉基乌里2在Dynamena pumila的口腔极处表现得保留.
- Brachyury3在幼虫神经细胞中表现出明显的表达,并且不受cWnt信号的控制,与Brachyury1和2不同.
结论:
- 布拉基尤里基因家族在类动物进化过程中通过重复扩大.
- 在水生动物中,brachyury对应物已经经历了次或新功能化.
- Brachyury3代表了水生动物轴向模式和神经发育的一个新的进化路径.
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