在mBDNF,皮质醇和亲BDNF急性变化的作用在预测老年认知表现中的作用
Jonna Nilsson1,2, Maria Ekblom3,4, Marcus Moberg3
1Swedish School of Sport and Health Sciences, Stockholm, Sweden. jonna.nilsson@gih.se.
Scientific reports
|June 9, 2023
概括
年龄较大的成年人.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 神经可塑性生物标志物,如来自大脑的神经营养因子 (BDNF) 和皮质醇,对于衰老中的认知功能至关重要.
- 这些生物标志物,学习和老年人的认知能力之间的关系需要进一步调查.
研究的目的:
- 在体力炼和认知训练后,检查血成熟的大脑衍生神经营养因子 (mBDNF),亲脑衍生神经营养因子 (pro-BDNF) 和皮质醇的急性变化.
- 确定这些生物标志物的共变性及其在老年人认知表现中的预测作用.
主要方法:
- 采集血液样本以测量mBDNF,亲BDNF和皮质醇的血度.
- 参与者进行了急性体力炼和认知训练干预.
- 在干预之前和之后评估认知表现.
主要成果:
- 在干预期间没有发现mBDNF,亲BDNF和皮质醇共同变化的证据.
- 确认了静止mBDNF和亲BDNF水平之间的积极关联.
- 探索性发现表明,从更高的mBDNF响应度与较低的皮质醇响应度和较低的静止皮质醇相结合,可以获得认知效益.
结论:
- 急性体力炼和认知训练似乎不会导致mBDNF,亲BDNF和皮质醇的同步变化.
- 特定的生物标志物概况,特别是较高的mBDNF反应能力和较低的皮质醇,可能与在衰老中保持认知功能有关.
- 未来的研究应该探索这些生物标志物概况与老年人群的认知性有关.
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