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优化抗体药物合物的安全性,用于患有固体瘤的患者

Paolo Tarantino^1,2,3,4, Biagio Ricciuti^3,5, Shan M Pradhan⁶

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Nature reviews. Clinical oncology

|June 9, 2023

概括

抗体-药物联合体 (ADC) 提供向癌症治疗,但面临毒性挑战. 目前正在进行的研究重点是改善早期和晚期固体瘤的ADC安全性和疗效.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
生物技术是生物技术.

背景情况:

在过去的五年里,抗体药物联合体 (ADC) 已经彻底改变了固体瘤治疗.
ADCs被设计为通过瘤特异性抗原向瘤细胞提供向的细胞毒性有效载荷.
尽管它们具有向性,但ADCs表现出显著的目标外和目标毒性,以及其他不良影响.

研究的目的:

在患有固体瘤的患者中审查ADC毒性的决定因素.
突出改善ADC耐受性和治疗结果的策略.
讨论ADC在早期和晚期癌症中的应用.

主要方法:

关于ADC设计和临床应用的当前文献的综述.
分析导致ADC相关毒性的因素.
检查正在进行的研究和临床试验以改善安全性.

主要成果:

在ADC设计的改进导致在治疗先进的固体瘤方面取得了重大进展.
与ADCs相关的毒性包括与有效载荷相关的效应,目标毒性和鲜为人知的不良事件.
目前提高ADC安全性的策略包括剂量/时间表优化,组件修改,生物标志物识别和先进诊断.

结论:

解决ADC的毒性对于扩大其临床使用至关重要,包括在治疗环境和组合疗法中.
改善ADC的耐受性预计将提高早期和晚期固体瘤患者的治疗结果.
对ADC安全性和有效性的持续研究将塑造未来的癌症治疗模式.

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