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Updated: Jul 27, 2025

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira
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Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira

Published on: August 14, 2021

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B组链球菌Cas9变种提供了可编程基因抑制和CRISPR-Cas转录效应的洞察力

Kathyayini P Gopalakrishna1, Gideon H Hillebrand2, Venkata H Bhavana1

  • 1University of Pittsburgh School of Medicine, Department of Pediatrics, Pittsburgh, PA, USA.

Communications biology
|June 9, 2023
PubMed
概括

B组链球菌Cas9通过非特异性DNA结合影响细菌的转录,而不是它的切割功能. 这一发现有助于开发新的工具来研究B组链球菌 (GBS) 基因功能.

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