孕产妇高血糖在怀孕和后代内化和外化行为
Sabrina Faleschini1, Myriam Doyon2, Mélina Arguin2
1Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, 02215, USA.
Maternal and child health journal
|June 9, 2023
概括
孕期糖尿病 (GDM) 在怀孕期间的暴露与3岁和5岁儿童的外部化行为增加有关. 较高的母体葡萄糖水平,但不是禁食葡萄糖,与这些行为问题相关.
科学领域:
- 生殖健康 生殖健康
- 儿童发展 儿童发展
- 内分泌学 在内分泌学.
背景情况:
- 妊娠期糖尿病 (GDM) 影响孕妇在怀孕期间的葡萄糖代谢.
- 孕产妇高血糖可能会影响胎儿发育和随后的儿童行为.
- 了解这些关联对于早期干预和长期儿童健康至关重要.
研究的目的:
- 为了研究妊娠期糖尿病 (GDM) 和孕妇在怀孕期间的血糖标志物之间的关系.
- 评估GDM暴露与3岁和5岁后代行为结果之间的关联.
- 为了确定孕妇在怀孕期间的高血糖是否预示着儿童的行为问题.
主要方法:
- 548对母婴对的前性队列研究 (Gen3G队列).
- 孕妇的血糖标志物通过口服葡萄糖耐受性测试 (OGTT) 在怀孕第二季度测量.
- 在3岁和5岁时使用优势和困难问卷 (SDQ) 和儿童行为检查表 (CBCL) 评估后代的行为.
主要成果:
- 暴露于GDM与3岁和5岁儿童的外部化行为得分较高有关.
- 在OGTT后1小时和2小时升高的葡萄糖水平与增加的外部化行为相关.
- 在禁食葡萄糖水平或血糖标志物与内化行为之间没有发现显著的关联.
结论:
- 孕期孕产妇高血糖症与子女外化行为风险增加有关.
- 这些发现凸显了GDM对儿童神经发育和行为的潜在影响.
- 进一步的研究可能会探索将母亲血糖与儿童行为结果联系起来的机制.
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