静态负荷和不良结果之间的关联在老年心力衰竭患者中,心脏衰竭患者中,心脏衰竭患者中,心脏衰竭患者中
Benchuan Hao1,2,3, Jianqiao Chen4, Yulun Cai1,3
1Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, Beijing, China.
BMC geriatrics
|June 9, 2023
概括
静态负荷 (AL) 显著增加了HFpEF的老年男性的死亡率和心力衰竭 (HF) 的入院风险. 这种基于生物标志物的测量有助于对这些患者的风险分层.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 身体生理学 身体生理学
背景情况:
- 静态负荷 (AL) 量化了慢性压力的累积生理磨损.
- 没有先前的研究研究过AL与心力衰竭预后与保留射出分数 (HFpEF) 之间的关联.
研究的目的:
- 检查HFpEF诊断的老年男性患者的全静电负荷和不良结果之间的关系.
- 评估AL对死亡率和HF住院治疗的预测价值.
主要方法:
- 一项前性队列研究包括1111名高FpEF的老年男性患者.
- 静态负荷是使用12个生物标志物来计算的.
- 考克斯的比例危险模型分析了AL和结果之间的关联.
主要成果:
- 更高的AL水平与所有原因,心血管和非心血管死亡率的风险增加有显著联系.
- 升高的AL也与HF入院的可能性更高相关.
- 在多变量调整和子组分析后,这些关联仍然显著.
结论:
- 增加的全静电负荷是HFpEF的老年男性预后不佳的重要预测因素.
- 使用随时可用的临床和实验室数据进行AL评估,可以帮助对HFpEF患者的风险分层.
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