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研究纵向乳房扫描密度测量与乳腺癌风险之间的关联:一种联合建模方法
Maya Illipse1,2, Kamila Czene1, Per Hall1,3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Breast cancer research : BCR
|June 9, 2023
概括
纵向乳房扫描密度 (MD) 轨迹与乳腺癌 (BC) 风险有关. 累积模型最好地捕捉到这种关联,为了解终身BC风险提供生物学相关性.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 生物统计学 生物统计学
背景情况:
- 乳腺扫描密度 (MD) 随着时间的推移而变化,可能表明乳腺癌 (BC) 风险.
- 之前的研究使用各种统计方法探索了MD轨迹和BC风险之间的联系.
研究的目的:
- 为了共同建模纵向MD轨迹和BC诊断的时间.
- 评估不同的统计模型来评估MD和BC风险之间的关联.
主要方法:
- 利用了来自瑞典大型乳腺扫描队伍 (年龄在40-80岁) 的数据.
- 采用了三个具有不同关联结构的联合模型 (JM):累积,当前价值和斜率以及当前价值.
- 在随访期间分析了518个BC诊断.
主要成果:
- 所有模型都表明MD轨迹和BC风险之间存在显著的关联.
- 结合累积或当前价值和斜率关联的模型显示出更好的合适度,而不是仅仅当前价值.
- 减少MD可能与增加瞬间BC风险有关,可能是由于查敏感性.
结论:
- 联合建模MD轨迹和BC诊断是可行的和有信息的.
- 提出一个具有累积关联结构的联合模型是理解终身BC风险的生物学上最相关和最合适的模型.
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