在SARS-CoV-2疫苗接种后心理药物血液水平的变化:两中心队列研究
Maxim Kuzin1,2,3, Fabian Gardin1, Markus Götschi1
1Clienia Schloessli, Private Psychiatric Hospital and Academic Teaching Hospital of the University of Zurich, Oetwil am See, Zurich, Switzerland.
Therapeutic drug monitoring
|June 9, 2023
概括
接种COVID-19疫苗显著改变了精神病药物的血水平,如奎蒂亚平和特拉佐. 对接种这些药物后的患者来说,监测和潜在的剂量调整至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 有限的证据表明,COVID-19疫苗接种可能会影响精神病药物治疗的结果.
- 缺乏关于COVID-19疫苗与克洛扎宾以外的精神药物相互作用的报道.
研究的目的:
- 研究COVID-19疫苗接种对各种精神药物的血水平的影响.
- 利用治疗药物监测来评估疫苗和精神病药物之间的药物相互作用.
主要方法:
- 在COVID-19疫苗接种之前和之后,从精神病医院住院患者中收集了12种精神药物的血水平.
- 包括在两个医疗中心接受稳定状态剂量药物的患者.
- 计算的疫苗接种后变化是基线水平的百分比.
主要成果:
- 在接种疫苗后一天内观察到奎蒂亚平 (+101.2%) 和特拉佐 (-38.5%) 的显著血水平变化.
- 疫苗接种后一周内,素 (活性成分,+31%) 和埃斯基塔洛普拉姆 (+24.9%) 的血水平有所增加.
- 包括来自16名患者的数据,确定了四种特定精神药物的重大变化.
结论:
- 提供了首次证据表明,在COVID-19疫苗接种后,埃斯基塔洛普拉姆,素,特拉佐和奎蒂亚平的血水平发生了显著的变化.
- 建议临床医生监测生物可用性变化,并考虑对这些药物的剂量调整.
- 强调在接受COVID-19疫苗的精神病患者安全监测的重要性.
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