中枢神经系统疾病治疗中的药物:开车的方法?
Marina G Gladkova1, Este Leidmaa2,3, Elmira A Anderzhanova4
1Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia.
Cells
|June 10, 2023
概括
针对表观基因组的流行药,通过影响多种遗传和环境因素,为治疗中枢神经系统 (CNS) 疾病提供了一种复杂的方法. 需要进一步的研究,以优化它们用于各种神经和精神疾病的使用.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 遗传学 遗传学是一种遗传学.
背景情况:
- 神经和精神疾病是复杂的,受遗传和环境的影响.
- 目前的治疗方法往往针对单一的途径,限制了疗效.
- 表观遗传药物 (表观药物) 为中枢神经系统疾病提供了多目标的治疗方法.
研究的目的:
- 审查基本的病理机制,以在中枢神经系统疾病中实现最佳的药物向.
- 探索在治疗神经退行性,神经发育性和精神疾病方面,抗生素的潜力.
- 确定在药物开发和应用方面需要改进的领域.
主要方法:
- 对流行病药物的临床前和临床数据的审查.
- 对流行药对表观遗传修饰的影响的分析.
- 对抗药对神经炎症,神经和蛋白质病变的影响的检查.
主要成果:
- 基因组脱乙酶抑制剂 (HDACis) 和DNA甲基转移酶抑制剂 (DNMTis) 显示出超出癌症治疗范围的前景.
- 药物调节神经炎症,神经营养因子 (如BDNF) 和关键蛋白质 (粉样蛋白,,α-synuclein).
- 目前的流行病药物需要优化疗效,降低毒性,以及特定的中枢神经系统疾病治疗方案.
结论:
- 由于其广泛的作用机制,Epidrugs具有治疗神经退行性疾病的潜力.
- 进一步的开发对于应用epidrugs用于神经发育,精神病和成障碍至关重要.
- 描述生活方式影响的表观遗传机制可能会揭示中枢神经系统疾病的新治疗点.
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