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Updated: Jul 27, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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低CDK活动和APC/CC的增强退化

Fanghua Li1,2, Emil Mladenov1,3, Yanjie Sun1,2

  • 1Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

Cells
|June 10, 2023
PubMed
概括

替代末端结合 (alt-EJ) DNA 修复受CtIP水平的调节,这些CtIP水平在G1细胞中较低,在G0细胞中由于降解而无法检测到. 抑制CtIP降解恢复了G0细胞中的alt-EJ,保持了基因组稳定性.

关键词:
在APC/C中,使用的是APC/C.这些CDK是CDK.CtIP 的意思是"共同的知识产权".在DNA末端切除过程中.修复DNA的修复DNA的修复在 RPA RPA 中使用.在 alt-EJJ.电离辐射辐射的电离辐射.脉冲场凝电泳是一种脉冲场凝电泳.修复DNA双链断裂的过程

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