炎症比率作为切除胃腺癌的生存预后因素
Vlad-Ionuţ Nechita1,2, Nadim Al-Hajjar2,3, Daniel-Corneliu Leucuța1
1Department of Medical Informatics and Biostatistics, "Iuliu Hațieganu" University of Medicine and Pharmacy, Louis Pasteur Street, No. 6, 400349 Cluj-Napoca, Romania.
Diagnostics (Basel, Switzerland)
|June 10, 2023
概括
手术前中性粒细胞与淋巴细胞比率 (NLR) 的升高与胃癌患者的整体存活率较差有关. 其他炎症标志物,如血小板与淋巴细胞比率 (PLR),淋巴细胞与单细胞比率 (LMR) 和全身免疫炎症指数 (SII) 没有显示预后值.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物统计学 生物统计学
背景情况:
- 胃癌仍然是一个重大的全球健康挑战.
- 确定可靠的预后标志物对于优化患者管理至关重要.
- 炎症生物标志物越来越多地被认为是它们在癌症预后中的潜在作用.
研究的目的:
- 调查关键炎症生物标志物与切除胃腺癌患者的整体存活率之间的关联.
- 为了确定中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),淋巴细胞与单细胞比率 (LMR) 和全身免疫炎症指数 (SII) 的预后值.
主要方法:
- 一项回顾性队列研究,涉及549名患有切除胃腺癌的患者.
- 数据收集了六年时间 (2016-2021年).
- 使用单变量和多变量COX比例危险模型分析的整体生存率.
主要成果:
- 较高的中性粒细胞与淋巴细胞比率 (NLR) 被确定为较低整体存活期的独立预后因素 (HR = 1.068,95% CI 1.011-1.12).
- 对于血小板与淋巴细胞比率 (PLR),淋巴细胞与单细胞比率 (LMR) 或全身免疫炎症指数 (SII) 没有观察到显著的生存差异.
- R1切除边缘和晚期瘤/节点阶段与明显较低的中位生存率相关.
结论:
- 手术前升高的NLR是切除胃腺癌患者总生存率降低的重要预测因素.
- 在这个患者队列中,PLR,LMR和SII似乎没有预后价值.
- 作为一种有价值,易于获得的胃癌风险分层生物标志物,NLR是非常有用的.
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