Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bone Disorders01:29

Bone Disorders

3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
Bone Remodeling01:40

Bone Remodeling

38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

11.3K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
11.3K
Fractures: Bone Repair01:27

Fractures: Bone Repair

3.4K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.4K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

4.0K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
4.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Humanized Knock-in Mouse Model of the PSEN1 V97L Mutation from a Major Chinese Alzheimer's Disease Pedigree Reveals Early Neuroinflammation.

Neuroscience bulletin·2026
Same author

Mitral valve surgery combined with on-pump coronary artery bypass grafting (CABG) versus off-pump or on-pump beating heart CABG: a retrospective cohort study.

Journal of thoracic disease·2026
Same author

SnRK2 and MLKs orchestrate FREE1 nuclear retention through phosphorylation to regulate ABA signaling in Arabidopsis.

Plant science : an international journal of experimental plant biology·2026
Same author

Differential modal gain optimization for weakly-coupled few-mode multi-core erbium-doped fiber amplifiers.

Optics express·2026
Same author

Targeting BRD2 and BRD4 inhibit the growth of KSHV-infected immortalized endothelial cells through suppression of LANA translation.

PLoS pathogens·2026
Same author

Targeting Hyaluronan Signaling Overcomes Primary Effusion Lymphoma Cells Resistance to Rapamycin.

Biological procedures online·2026
Same journal

Correction: Luca et al. Global and Regional Diagnostic Results of Progress Toward Cervical Cancer Elimination, According to the WHO Strategy: A Systematic Literature Review with Narrative Synthesis. <i>Diagnostics</i> 2026, <i>16</i>, 1224.

Diagnostics (Basel, Switzerland)·2026
Same journal

Association Between Systemic Inflammatory Response Biomarkers and Disease Activity in Systemic Lupus Erythematosus: A Multi-Center Retrospective Study.

Diagnostics (Basel, Switzerland)·2026
Same journal

Vertebrogenic Low Back Pain and Basivertebral Nerve Ablation: A Review of Mechanisms, Imaging-Driven Selection, and Clinical Outcomes.

Diagnostics (Basel, Switzerland)·2026
Same journal

Multivalvular Carcinoid Heart Disease: The Role of Echocardiography in Diagnosis and Selection for Heterotopic Bicaval Valve Implantation.

Diagnostics (Basel, Switzerland)·2026
Same journal

Data-Efficient and Explainable Multimodal Survival Prediction in NSCLC Using Deep Image Embeddings, Clinical Variables, and Gradient-Boosted Trees.

Diagnostics (Basel, Switzerland)·2026
Same journal

Anomalous Left Coronary Artery from the Pulmonary Artery: Cinematic Volume Rendering Technique for Enhanced Anatomic Visualization.

Diagnostics (Basel, Switzerland)·2026
查看所有相关文章

相关实验视频

Updated: Jul 27, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

84.1K

多重骨损伤是继发于多重骨损伤的次要原因.

Lu Dai1, Yanyan Wu2, Xi Zhou3

  • 1Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.

Diagnostics (Basel, Switzerland)
|June 10, 2023
PubMed
概括
此摘要是机器生成的。

癌症菌菌菌 (Mycobacterium kansasii) 感染很少引起骨质病,特别是在免疫能力强的人群中. 这一案例突出显示了一例罕见的脊柱骨损坏,原因是M. kansasii肺部疾病在一个免疫能力强的病人.

关键词:
这种细菌是Mycobacterium kansasii.破坏骨破坏骨的破坏具有免疫能力的免疫能力.

更多相关视频

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

10.2K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

2.8K

相关实验视频

Last Updated: Jul 27, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

84.1K
Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

10.2K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

2.8K

科学领域:

  • 医学微生物学 医学微生物学
  • 传染性疾病 传染性疾病
  • 整形外科手术 整形外科手术

背景情况:

  • 癌症菌菌菌菌感染通常会影响免疫力低下的个体,主要导致肺部和传播性疾病.
  • 骨质病是Mycobacterium kansasii感染的一种不常见的表现.
  • 这种病例在免疫能力强的患者中是罕见的.

研究的目的:

  • 报告一个罕见的多重骨损伤病例,包括脊髓干扰,这是Mycobacterium kansasii肺部疾病的次要病例.
  • 强调这种罕见疾病的诊断挑战和临床表现.
  • 为了有助于对Mycobacterium kansasii骨质病的理解.

主要方法:

  • 案例报告展示与详细的成像数据.
  • 通过手术前的唾液检测和下一代手术内样本测序来确认诊断.
  • 临床管理包括紧急手术和抗结核治疗.

主要成果:

  • 一名44岁的免疫能力强的中国妇女出现了广泛的骨损伤,特别是脊椎.
  • 患者经历了残肢,表明疾病进展.
  • 通过微生物学和分子方法证实了Mycobacterium kansasii感染.
  • 使用抗结核治疗的治疗导致了患者的积极反应.

结论:

  • 由于Mycobacterium kansasii感染而导致的二次骨病症在免疫能力强的个体中异常罕见.
  • 早期和准确的诊断至关重要,尽管存在潜在的误诊挑战.
  • 这一案例强调了在骨损坏的差异诊断中考虑M. kansasii的重要性,即使在免疫能力强的患者中也是如此.