与老年乳腺癌患者和对照者的长度认知表现相关的遗传变异
Kelly Nudelman1,2,3,4, Kwangsik Nho2,4, Michael Zhang1,3
1Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Cancers
|June 10, 2023
概括
这项研究确定了与老年乳腺癌幸存者的认知衰退相关的遗传变异. 特定的基因变异与癌症治疗后的注意力,处理速度和执行功能下降有关.
科学领域:
- 遗传学 遗传学 是一个
- 神经科学是一个神经科学.
- 在瘤学瘤学.
背景情况:
- 癌症和治疗相关的认知衰退 (CRCD) 缺乏全基因组遗传研究.
- 了解CRCD遗传学对于管理癌症幸存者的长期副作用至关重要.
研究的目的:
- 在老年女性乳腺癌幸存者中识别与CRCD相关的遗传变异.
- 探索癌症治疗后认知变化的遗传基础.
主要方法:
- 在老年非转移性乳腺癌幸存者的全基因组关联研究 (GWAS) (N=325) 和匹配的对照 (N=340).
- 纵向评估的认知功能 (注意力,处理速度,执行功能,学习和记忆).
- 线性回归模型分析了SNP和基因丰富与癌症状况的相互作用,控制共变量.
主要成果:
- 两种单核酸多态 (SNP),rs76859653 (在HMCN1基因中) 和rs78786199 (跨基因),与携带小等位基因的癌症患者的一年APE得分较低有关.
- 基因水平分析显示,SNP的POC5基因丰富与患者和对照者之间的纵向LM性能差异有关.
- 与幸存者的认知衰退相关的SNP,但不是对照,属于循环核酸化酶家族.
结论:
- 新的遗传基因位点,包括特定的SNP和POC5基因,可能会导致CRCD易感性.
- 循环核酸化酶家族基因与认知功能有关,可能影响CRCD风险.
- 这些发现为未来对CRCD遗传基础的研究提供了基础.
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