对于花色细胞瘤和交感性偏结瘤的手术后的长期结果
Francesca Torresan1, Arianna Beber1, Donatella Schiavone1
1Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy.
Cancers
|June 10, 2023
概括
长期随访对于染细胞瘤和交感性偏角质瘤 (PHEO/sPGL) 患者至关重要. 即使是看似良性和零星的瘤也具有显著的复发风险,需要终身监测.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 染细胞瘤和交感性偏瘤 (PHEO/sPGL) 的预后难以预测.
- 长期随访数据有限,特别是在良性和零星变异方面.
研究的目的:
- 分析被诊断为PHEO/sPGL.患者的长期结果.
- 评估不同PHEO/sPGL亚型的复发和转移风险.
主要方法:
- 一项单一中心研究分析了170名为PHEO/sPGL进行手术的患者.
- 收集和分析了瘤行为,复发和转移性传播的数据.
主要成果:
- 10年复发风险为13%,在30年后增加到33%.
- 与遗传变异 (6.5%) 相比,零星变异显示出显著的20年复发风险 (38%).
- 转移性复发风险甚至存在于看似良性的变体中 (5年后1%).
结论:
- 对所有PHEO/sPGL患者,包括那些明显良性和零星瘤患者,终身随访至关重要.
- 早期诊断和持续监测对于管理长期复发性疾病至关重要.
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