在卵巢癌维持治疗期间喝酒还是不喝酒?
1Profesor Sznurkowski Podmiot Leczniczy, 81-346 Gdynia, Poland.
Cancers
|June 10, 2023
概括
对于卵巢癌,保留贝瓦西祖马布作为二线维持疗法. 向响应第一线化疗的晚期卵巢癌患者提供PARP抑制剂维持疗法.
科学领域:
- 在瘤学瘤学.
- 妇科瘤学 妇科瘤学
- 临床试验设计 临床试验设计
背景情况:
- 用PARP抑制剂和贝瓦齐祖马布进行维护疗法已被批准用于卵巢癌.
- 由于对药物的重复使用的限制,最优的测序具有挑战性.
- 对于卵巢癌的维持治疗选择,需要指导方针.
研究的目的:
- 建立基于证据的卵巢癌维持治疗指南.
- 确定最有效的治疗策略和治疗顺序.
- 评估维持疗法选择对医疗保健系统的影响.
主要方法:
- 使用AGREE II指南评估工具来评估科学证据.
- 制定了六个关键问题,涉及药物的重复使用,疗效和比较疗效.
- 评估了组合维持疗法的潜在益处和经济影响.
主要成果:
- 建议使用贝瓦西祖马布作为二线维持疗法.
- 在第一线化疗后,应向晚期卵巢癌患者提供PARP抑制剂维持疗法.
- 对贝瓦齐祖马布疗效的分子预测因素需要进一步的研究.
结论:
- 为选择卵巢癌维持治疗提供了基于证据的框架.
- 建议旨在优化治疗顺序和患者的治疗结果.
- 进一步的研究对于完善指南和改善患者护理至关重要.
相关概念视频
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
356
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
356
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
209
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
209


