检查点抑制剂诱导的类风湿性免疫介导不良反应患者的calprotectin
Beatriz Frade-Sosa1, Chafik Alejandro Chacur1, Josep M Augé2
1Department of Rheumatology, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Cancers
|June 10, 2023
概括
在患有因免疫检查点抑制剂 (ICI) 治疗而出现风湿性免疫相关不良事件 (irAEs) 的患者中,calprotectin血清水平升高. 这一发现表明calprotectin可能表明这些患者的炎症活性.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 在瘤学瘤学.
背景情况:
- 免疫检查点抑制剂 (ICI) 可以导致免疫相关的不良事件 (irAEs),包括类风湿综合征.
- 评估irAEs的生物标志物对于患者管理至关重要.
研究的目的:
- 评估ICI治疗诱导的风湿性IRAE患者的血清calprotectin水平.
- 为了确定calprotectin能否在这个人群中作为炎症活动的标记物.
主要方法:
- 追溯观察性研究,将风湿性IRAE患者的calprotectin水平与对照者 (风湿性关节炎患者,健康人群和没有IRAE的ICI治疗患者) 的水平进行比较.
- 分析calprotectin在使用接收器操作特征 (ROC) 曲线识别活跃类风湿病的性能.
主要成果:
- 与类风湿性关节炎 (3.19 μg/mL) 和健康对照 (3.81 μg/mL) 相比,患有类风湿性irAEs的患者表现出较高的平均calprotectin水平 (5.15 μg/mL).
- 活性炎症的irAE患者 (8.43μg/mL) 和RA患者 (3.94μg/mL) 的calprotectin水平显著更高.
- 在ROC分析中,calprotectin在识别风湿性irAEs的炎症活性方面具有强大的区分能力 (AUC0.864).
结论:
- 血清calprotectin可能是一个有价值的生物标志物,用于评估风湿性irAEs患者的炎症活性.
- 这些发现支持calprotectin在监测接受免疫检查点抑制剂治疗的患者中的潜在使用.
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