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用SPY发酵的抗肥胖作用

Taewook Kang^1,2, Jin Ree^1,2, Joo-Woong Park²

¹Department of Biotechnology, Graduate School, The Catholic University of Korea, Bucheon 14662, Republic of Korea.

Foods (Basel, Switzerland)

|June 10, 2023

概括

这项研究表明,Lactobacillus rhamnosus BST-L.601及其发酵产品SPY可以帮助预防肥胖. SPY有效地减少了细胞和动物模型中的脂肪积累,为功能性食品提供了潜力.

科学领域:

微生物学微生物学
营养科学营养科学
生物化学生物化学

背景情况:

肥胖是一个日益严重的全球健康问题.
饮食干预和益生菌正在探索抗肥胖作用.
拉科巴西勒斯 (Lactobacillus rhamnosus) BST-L.601及其发酵产品 (SPY) 显示出潜力.

研究的目的:

为了研究乳杆菌rhamnosus BST-L.601和SPY.的抗肥胖作用.
评估它们在体外和体外对脂肪生成和脂质生成的影响.

主要方法:

在体外:用SPY治疗的3T3-L1预adipocytes.
在体内:高脂肪饮食诱导的肥胖小鼠口服SPY或BST-L.601.1.
对脂肪生成标记物,脂质积累,体重,脂肪组织和血清脂质概况的分析.

主要成果:

在3T3-L1细胞中,SPY剂量依赖性降低了脂质积累和脂肪原标记.
在肥胖小鼠中,SPY的使用显著降低了体重,肝脏重量,脂肪细胞大小和脂肪组织.
与单独使用BST-L.601相比,SPY在减肥方面表现出更大的有效性.
SPY和BST-L.601都降低了血清总胆固醇,LDL胆固醇和瘦素水平.

结论:

拉科巴西勒斯拉姆诺斯BST-L.601及其发酵产品SPY有效抑制脂肪生成和脂质生成.
这些发现表明它们在功能性食品中对肥胖管理和预防的有用性.

关键词:

乳杆菌 rhamnosusus 的乳杆菌.这是一种抗肥胖的药物.发酵的甜是一种发酵的甜.益生菌益生菌益生菌益生菌是一种益生菌.

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