植物体补充剂提供供应
Onanong Nuchuchua1, Ratchanon Inpan2, Wanwisa Srinuanchai1
1National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand.
Foods (Basel, Switzerland)
|June 10, 2023
概括
Gymnema inodorum (GI) 的植物体通过改善植物营养素的输送来增强抗炎作用. 然而,植物体配方在本研究中略有降低了抗胰岛素耐药性.
科学领域:
- 植物化学 植物化学
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- Gymnema inodorum (GI) 是一种泰国绿叶植物,具有对代谢糖尿病控制的潜力.
- GI的活性化合物的非极性特性限制了它们的生物可用性.
- 植物体技术提供了一种新的方法来增强植物营养素的输送.
研究的目的:
- 为了开发GI叶子提取物的植物体配方.
- 为了评估GI植物体的抗炎和抗胰岛素耐药活性.
- 评估植物酶封装对GI植物营养素生物可用性的影响.
主要方法:
- 将GI提取物制成植物体 (160-180nm纳米粒子).
- 植物体结构,表面电荷和植物营养素封装的表征.
- 在体外评估抗炎活性 (巨细胞中氧化的产生) 和抗胰岛素耐药性 (脂肪细胞中葡萄糖吸收和脂质降解).
主要成果:
- 植物体成功地将GI提取物分散在水溶液中,形成球形纳米粒子.
- 胃肠道植物化合物嵌入了脂双层中,改变了表面电荷至-35至-45mV.
- 植物体显著增强了胃肠道提取物的抗炎活性,但略有降低了其抗胰岛素抵抗作用.
结论:
- 纳米植物体配方是胃肠道植物化学物质的有希望的载体,特别是在抗炎症应用中.
- 脂成分可能调节GI提取物的抗胰岛素抵抗作用.
- 需要进一步的研究来优化植物体配方,以全面预防T2DM.
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