在超重或肥胖的青少年中,负载后1小时的血葡萄糖和改变的葡萄糖代谢概况
Procolo Di Bonito1, Giuliana Valerio2, Maria Rosaria Licenziati3
1Department of Internal Medicine, "S. Maria delle Grazie" Hospital, 80078 Pozzuoli, Italy.
在口服葡萄糖耐受性测试 (OGTT) 中,一小时葡萄糖的切断值为133 mg/dL,比155 mg/dL的切断值更好地识别出患有超重/肥胖的年轻人患有葡萄糖耐受性损失 (IGT) 和心脏代谢风险 (CMR) 的风险.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢健康 代谢健康
- 评估心血管风险评估
背景情况:
- 两种值,133和155 mg/dL,用于定义年轻人高高的1小时口服后葡萄糖耐受性测试 (OGTT) 葡萄糖水平 (G60).
- 确定适当的门值对于在危险儿科群体中早期检测代谢功能障碍至关重要.
研究的目的:
- 为了比较G60切断值 (133与155毫克/分升) 在识别超重/肥胖 (OW/OB) 青少年中孤立降低葡萄糖耐受性 (IGT) 和心脏代谢风险 (CMR) 的实用性.
- 确定哪个G60值更有效地标志着年轻人具有异常的葡萄糖代谢和相关风险因素.
主要方法:
- 对1199名患有OW/OB和正常禁食葡萄糖/HbA1c的年轻人的数据进行分析.
- 基于G60水平的参与者分类,使用两个建议的切断值:≥133 mg/dL与≥155 mg/dL.
- 评估心脏代谢风险因素,包括G120,胰岛素耐药性 (IR),胰岛素敏感性 (IS),排放指数 (DI),甘油三和高血糖比率 (TG/HDL) 以及氨酸转移酶 (ALT).
主要成果:
- 具有更高G60水平的年轻人 (无论切断值) 显示出明显更高的G120,IR,TG/HDL和ALT,以及较低的IS和DI.
- 与G60≥133 mg/dL组相比,G60≥155 mg/dL组的IGT,IR,低IS,高TG/HDL,高ALT和低DI的患病率提高了50%.
- 133 mg/dL的切断值在识别IGT的年轻人和改变的CMR概况方面表现出更大的灵敏度.
结论:
- 133 mg/dL的OGTT后1小时的葡萄糖切断值比155 mg/dL更有效,用于识别超重/肥胖的年轻人有高风险的IGT和不良心脏代谢结果.
- 这一发现支持使用较低的G60值来加强对患有代谢综合征风险的儿科患者群体的查和早期干预.
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