在罕见疾病患者中用莫里斯基尺度测量自我报告的药物坚持:系统性审查和元分析
Ana María García-Muñoz1, Desirée Victoria-Montesinos1, Begoña Cerdá1
1Faculty of Pharmacy and Nutrition, Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, 30107 Murcia, Spain.
Healthcare (Basel, Switzerland)
|June 10, 2023
概括
在罕见疾病中,药物坚持是高度可变的,低坚持影响了41.4%的患者. 这一元分析强调了罕见病治疗适用性的挑战.
科学领域:
- 药理学和公共卫生
- 罕见疾病研究 罕见疾病研究
- 系统性审查和元分析
背景情况:
- 由于罕见疾病的异质性,高死亡率和低患病率,它们带来了重大的社会挑战.
- 药物坚持性研究在罕见疾病中很少,通常受到治疗可用性限制.
研究的目的:
- 进行一项元分析,评估在流行罕见疾病中药物坚持水平.
- 综合现有关于罕见疾病群体治疗坚持情况的数据.
主要方法:
- 系统性审查和元分析注册在PROSPERO (CRD42022372843) 并遵守PRISMA指南.
- 从18项涉及1559名参与者的研究中收集的数据,使用莫里斯基药物坚持量表 (MMAS-8).
主要成果:
- 从54个记录中确定了18项研究,其中包括1559名参与者 (54.18%是女性).
- 对使用MMAS-8的8项研究进行分析,对依从性进行分类:低41.4%,中等30.4%,高28.2%.
- 参与者的平均年龄在84岁以下.
结论:
- 在罕见疾病中,对药物的坚持表现出显著的变化.
- 影响药物适用性的因素有助于观察到的坚持差异.
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