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Updated: Jul 27, 2025

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

在低温透期间对新陈代谢的当前见解 - - 范围审查

Laurence Verstraeten¹, Rutger Den Abt¹, Bart Ghesquière^2,3

¹Laboratory of Abdominal Transplantation KU Leuven, Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.

Journal of clinical medicine

|June 10, 2023

概括

在低温 perfusion 保存期间,脏在代谢上保持活跃. 使用代谢标记物的进一步研究对于充分了解代谢和改善器官保存技术至关重要.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
移植移植移植移植
代谢研究研究代谢研究

背景情况:

在低温输液期间保存脏对于移植成功至关重要.
在低温条件下了解代谢是不完整的.
研究中的异质性使 perfusion 期间代谢的解释变得复杂.

研究的目的:

审查和综合现有关于低温 perfusion 保存期间代谢的知识.
为了确定在低温输液期间了解脏代谢活动的差距.
突出在器官保存方面的未来研究领域.

主要方法:

对科学文献进行了全面的范围审查.
搜索的数据库包括PubMed,Embase,科学网络和Cochrane.
包括在1970-2023年间发表的关于低温 perfusion (<12°C) 期间代谢的研究.

主要成果:

分析了52项涉及狗,子,猪和人类的研究.
脏在各种环境下在低温 perfusion 期间表现出代谢活动.
在所有纳入的研究中,注意到存在重大偏差和异质性风险.
代谢途径受到 perfusate 组成,氧化和先前存在的损伤的影响.

结论:

低温输液期间的代谢是复杂的,并未完全理解.
代谢标记物对于阐明活性代谢途径至关重要.
未来的研究应该专注于受伤的代谢干扰和低温氧化 perfusion 中的氧气水平.

关键词:

低温脏 perfusion 的情况.孤立的器官 perfusion perfusion 是一个孤立的器官 perfusion.同位素标记剂是一种同位素标记剂.的新陈代谢的新陈代谢保护脏保护脏范围审查范围审查审查

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