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健康成年患者急性细菌脑膜炎:一项前性队列研究

Virginia Pomar¹, Natividad Benito^1,2,3, Pol Duch⁴

¹Infectious Diseases Unit, Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau-Institut d'Investigació Biomèdica Sant Pau, Universitat Autònoma de Barcelona, 08025 Barcelona, Spain.

Journal of clinical medicine

|June 10, 2023

概括

健康成年人的细菌性脑膜炎 (BM) 越来越多地出现在老年人身上. 最近的趋势显示,肺炎球菌和李斯特菌感染正在转向肺炎球菌和李斯特菌感染,生存率有所提高.

科学领域:

传染性疾病传染性疾病
神经学神经学
流行病学流行病学

背景情况:

自发性细菌性脑膜炎 (BM) 通常与并发性疾病有关.
在以前健康的个体中,BM的特征和结果需要进一步描述.

研究的目的:

分析自发细菌性脑膜炎 (BM) 在没有并发症的成年人特征和结果的时间趋势.
为了比较两个不同的时间段的BM病例 (1982年至2000年和2001年至2019年).

主要方法:

在单一的高等大学医院进行前性观察队列研究.
包括328名被诊断患有BM的成年患者.
1982-2000年和2001-2019年间的BM特征和住院死亡率的比较.

主要成果:

患者的中位年龄从37岁增加到45岁.
脑膜炎球菌性脑膜炎减少了 (56%至31%),而菌性脑膜炎增加了 (1.2%至8%).
系统性并发症增加,但在调整后,住院死亡率没有显示期间之间的显著差异 (10.4%对比9.2%).

结论:

没有近年来发展BM的并发症的成年人是老年人.
最近的BM病例更频繁地是由肺炎球菌或菌病原体引起的,并且存在更多的全身并发症.
调整后的分析表明,在最近的时期,住院死亡的风险较低.

关键词:

这是细菌性脑膜炎.脑脊液分析脑脊液分析一个健康的病人,一个健康的病人.发生自发性脑膜炎.

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