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青春期前饮食正常化恢复了年轻小鼠的认知功能

Wenqian Sun1, Hidemasa Okihara1, Takuya Ogawa1

  • 1Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138510, Japan.

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概括

在青春期之前通过切换到更严格的饮食来恢复食,可显著改善小鼠的认知功能. 然而,延迟这种饮食变化会损害学习和记忆,这强调了器发育的关键窗口.

关键词:
认知功能障碍 认知功能障碍增长和发展的增长和发展.在海马体内,海马体消化 消化 消化 消化收回回收回收的恢复

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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 营养科学 营养科学

背景情况:

  • 对于中枢神经系统 (CNS) 的发育和功能至关重要.
  • 低能力与儿童和成人认知功能障碍有关.
  • 食对认知功能影响的关键发育期尚不清楚.

研究的目的:

  • 在小鼠模型中研究恢复口对学习和记忆的影响.
  • 确定功能影响认知发育的关键时间窗口.

主要方法:

  • 开发一个小鼠模型,在不同的时间点操纵饮食纹理 (软到正常的饮食).
  • 行为测试用于评估学习和记忆.
  • 微型CT,组织学和生化分析口面结构和海马功能.

主要成果:

  • 早期的饮食纠正 (青春期前) 恢复了口和认知功能,增强了神经发生和关键信号通路 (ERK,CREB,BDNF).
  • 晚期的饮食纠正 (青春期后) 无法完全恢复口,导致认知功能受损,神经元损失,并减少海马神经发生.
  • 在青少年和青少年时期之间存在一个关键的发育窗口,用于食对认知功能的影响.

结论:

  • 适当的食物质地和早期干预对于预防儿童相关的认知障碍至关重要.
  • 在小鼠中,口功能与小鼠在青春期的认知功能有功能联系.
  • 通过适当的饮食质地恢复可以积极影响神经发育和认知结果.