在多发性硬化症患者接种SARS-CoV-2疫苗后复发的频率和预测因素:从长度观察研究中获得的临时结果
Niklas Frahm1,2, Firas Fneish1, David Ellenberger1
1MS Forschungs- und Projektentwicklungs-gGmbH (MS Research and Project Development gGmbH [MSFP]), 30171 Hannover, Germany.
Journal of clinical medicine
|June 10, 2023
概括
大多数患有多发性硬化症 (PwMS) 的人在接种COVID-19疫苗后没有出现复发. 在那些没有接受免疫治疗或最近有过复发的患者中,复发更为常见.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 对SARS-CoV-2的疫苗接种对于保护患有多发性硬化症 (PwMS) 的人免受严重的COVID-19的感染至关重要.
- 一些PwMS表示对接种疫苗犹,因为担心潜在的副作用或疾病活动增加.
- 了解疫苗接种后复发率对于有关多发性硬化症管理和疫苗接种策略的知情决策至关重要.
研究的目的:
- 为了确定SARS-CoV-2疫苗接种后多发性硬化症 (PwMS) 患者复发的频率.
- 在PwMS中确定与疫苗接种后复发相关的预测因素.
- 为了比较接种疫苗的PwMS中复发率与疫苗接种前率和未接种疫苗的参考群体.
主要方法:
- 一项前性,观察性,德国范围内的在线调查与PwMS进行,这些人至少接受了一次SARS-CoV-2疫苗接种.
- 通过基线和后续调查收集了患者报告的人口统计数据,MS特征和疫苗接种后现象.
- 计算了每年复发率 (ARR),并将研究队列 (疫苗接种前和后) 与来自德国多发性硬化病登记处的匹配参考队列进行了比较.
主要成果:
- 接种疫苗后的复发报告为9.3%的PwMS (247/2661).
- 研究队伍的疫苗接种后ARR为0.189,与匹配的未接种疫苗的参考组 (ARR0.147) 相似.
- 接种疫苗后复发的关键预测因素包括没有接受免疫治疗 (OR=2.09) 和最后一次接种疫苗前复发和第一次接种疫苗之间的时间间隔较短 (OR=0.87).
结论:
- 该研究发现,在SARS-CoV-2疫苗接种后,与接种前或未接种疫苗的组相比,多发性硬化症 (PwMS) 患者的复发活动总体没有增加.
- 由于害怕疾病活动增加而犹于接种疫苗的情况,可以通过这些证据来解决.
- 停止免疫治疗和最近复发史是PwMS疫苗接种后复发的重要预测因素,需要仔细考虑.
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