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Updated: Jul 27, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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免疫检查点抑制剂肝炎的组织学特征和管理:一项回顾性描述性研究

Lucia Parlati1,2, Kennie Marcin1,2, Benoit Terris1,3

  • 1Faculty of Medicine, Université Paris Cité, Cochin Site, 24 rue du Faubourg Saint-Jacques, F-75006 Paris, France.

Journal of clinical medicine
|June 10, 2023
PubMed
概括

免疫检查点抑制剂相关的药物诱导肝损伤 (ICI-DILI) 肝活检不会改变治疗方法,但可以识别对皮质类固醇反应不佳的胆炎特征患者.

关键词:
与ICI相关的药物诱导性肝损伤 (ICI-DILI)肝炎肝炎是什么意思 肝炎肝炎是什么意思ICI-DILI 的组织学.免疫检查点抑制剂 (ICI)

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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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