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大脑血管病变和微型心脏病发作之间的关系在一个基于社区的老年人队列中

Mo-Kyung Sin¹, Yan Cheng², Jeffrey M Roseman³

¹College of Nursing, Seattle University, Seattle, WA 98122, USA.

Journal of clinical medicine

|June 10, 2023

概括

大脑动脉样硬化与微型心脏病发作有着显著的联系,影响了它们的存在,数量和位置. 大脑粉样血管病变显示出较弱的关联,表明动脉样硬化.

科学领域:

神经学神经学
病理学病理学病理学
神经科学是一个神经科学.

背景情况:

大脑微发作与认知衰退和痴呆症有关.
小血管疾病,包括大脑动脉样硬化和大脑粉样血管病变 (CAA),与微型心脏病发作有关.
这些血管病变和微心脏病特征之间的具体关系仍然不完全理解.

研究的目的:

研究大脑动脉样硬化和CAA严重程度和位置与大脑微发作存在,数量和位置之间的关联.
为了澄清这两种小血管疾病在微心脏病发作中的不同作用.

主要方法:

分析了成年人思维变化 (ACT) 研究中842名参与者的临床和尸检数据.
脑动脉样硬化和CAA严重程度 (无至严重) 和位置 (皮层,皮层下) 的量化.
对微型心脏病发作进行概率比率 (OR) 和95%信心区间 (CI) 的估计,对共变量进行调整.

主要成果:

中度和严重的大脑动脉样硬化与微型心脏病发作的增加存在 (OR 2.16-4.63) 和数量 (OR 2.25-4.91) 有关.
这些关联扩展到皮层和皮层以下的微发作.
大脑粉样性血管病变显示,与所有严重程度的微型心脏病发作的存在,数量或位置的联系很弱,不显著.

结论:

大脑动脉样硬化与大脑微发作的发生,数量和分布密切相关.
在这个队列中,大脑粉样血管病变在微型心脏病发作中的作用有限.
需要进一步的研究来阐明小血管疾病导致大脑微发作的确切机制.

关键词:

动脉样硬化症动脉样硬化症大脑粉样性血管病变 - 大脑粉样性血管病变皮质上皮质的皮层.微型心脏病发作微型心脏病发作皮质下皮层的皮质下皮层.

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