在与艾滋病毒相关的慢性阻塞性肺病 (COPD) 和肺部并发症中,循环节结合基因表达和调节
Kingshuk Panda1, Srinivasan Chinnapaiyan1, Md Sohanur Rahman1
1Department of Immunology and Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
International journal of molecular sciences
|June 10, 2023
概括
艾滋病毒感染者 (PLWH) 面临患慢性阻塞性肺病 (COPD) 的风险更高. 本综述探讨了乱的昼夜节律如何导致PLWH中COPD的发展,并讨论了潜在的治疗方法.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 时间生物学 时间生物学
背景情况:
- 艾滋病毒感染者 (PLWH) 易患慢性阻塞性肺病 (COPD),喘,健康状况较差.
- 联合抗逆转录病毒疗法 (cART) 改善了艾滋病毒患者的寿命,但与COPD的发病率更高有关,即使在年轻人中也是如此.
- 循环节律,身体的内部24小时周期,调节关键的生理过程,包括免疫反应和病毒复制,影响整体健康和疾病进展.
研究的目的:
- 阐明将昼夜时钟失调与艾滋病毒感染联系起来的机制.
- 检查昼夜基因干扰在PLWH中COPD的发展和进展中的作用.
- 探索潜在的治疗策略,以重置昼夜时钟,减少呼吸道炎症.
主要方法:
- 本综述综合了关于昼夜生物学和艾滋病毒病理生理学的当前研究.
- 它分析了核心时钟和时钟输出基因失调对PLWH慢性炎症和周围昼夜节律的影响.
- 该审查讨论了旨在恢复昼夜节律平衡的新兴治疗目标.
主要成果:
- 昼夜基因的调节失调与PLWH中COPD的风险增加和进展有关.
- 异常的周围昼夜节律和慢性炎症是艾滋病毒中昼夜时钟中断的关键后果.
- 艾滋病毒,cART和昼夜机制之间的相互作用有助于增加COPD发病率.
结论:
- 循环时钟失调是艾滋病毒感染者中COPD病变的一个重要因素.
- 准昼夜节律为新型治疗干预提供了一个有希望的途径,以管理呼吸道炎症并减轻PLWH中COPD的进展.
- 对慢性治疗的进一步研究可能为改善艾滋病毒感染人口的呼吸系统健康提供有效的策略.
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