膜补充调节者的腹表达在患有感染腹炎的腹透析患者中降低
Sosuke Fukui1,2, Masashi Mizuno1,2, Mitsuhiro Tawada1
1Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
International journal of molecular sciences
|June 10, 2023
概括
患有真菌或Pseudomonas aeruginosa腹膜炎的腹膜透析患者经历了严重的腹膜损伤. 这些损伤降低了保护补体调节器,增加了对进一步损伤的易感性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 菌和Pseudomonas aeruginosa感染与腹膜透析 (PD) 腹膜炎的不良结果有关.
- 补充调节剂 (CRegs) 保护组织,但它们在PD周周炎中的作用尚不清楚.
研究的目的:
- 在患有腹膜炎的PD患者中调查腹膜组织损伤和CReg表达 (CD46,CD55,CD59).
- 为了比较真菌/Pseudomonas aeruginosa腹膜炎 (P1) 和格拉姆阳性细菌腹膜炎 (P2) 之间的损伤和CRegs.
主要方法:
- 来自PD患者进行导管切除的腹膜活检组织的分析.
- 评估腹膜炎的严重程度,CReg表达和补充激活产品 (C3,C5b-9).
- 没有腹膜炎的患者,P1和P2之间的比较.
主要成果:
- 腹膜损伤与CReg表达相反相关;腹膜炎与对照组相比降低了CRegs.
- 腹损伤在P1比P2更严重.
- P1显示CReg表达较低,C5b-9水平比P2高.
结论:
- 在真菌和Pseudomonas aeruginosa腹膜炎中严重的腹膜损伤与CReg表达的减少有关.
- 降低CRegs和增加补体激活 (C3,C5b-9) 可能会增加这些患者对进一步腹损伤的敏感性.
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