弥合周围神经的差距:从目前的策略到管道设计的未来前景
Elena Stocco1,2,3,4, Silvia Barbon1,3,4, Aron Emmi1
1Section of Human Anatomy, Department of Neuroscience, University of Padova, 35121 Padova, Italy.
International journal of molecular sciences
|June 10, 2023
概括
对于带有组织损失的严重外周神经损伤 (PNI),当前的移植,如自体移植和空洞导管是不够的. 未来的神经再生策略重点是先进的导管设计和细胞疗法,以更好地恢复.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 神经科学是一个神经科学.
背景情况:
- 带有物质损失的外周神经损伤 (PNI) 通常需要神经移植,当端到端接是不可能的.
- 目前的选择包括自体移植,全体移植和由合成或天然聚合物制成的各种空心神经导管,具有不同的吸收率.
研究的目的:
- 审查目前严重PNI恢复的替代方案.
- 突出神经再生管道发展的有希望的未来战略.
主要方法:
- 对PNI的神经移植和中空神经管道的现有文献的审查.
- 对商业神经管道的材料,设计和临床批准的分析.
- 探索管道功能化和细胞增强中的新兴概念.
主要成果:
- 目前没有任何移植或导管选项完全符合解剖学和功能神经再生的要求.
- 商业中空管道使用不同的材料 (合成/天然聚合物) 具有不同的降解概况.
结论:
- 下一代神经导管应该专注于墙壁和光线组织/功能化.
- 有前途的策略包括多孔/沟壁,多通道光源,光源填充剂,以及细胞的结合 (例如,施万细胞,干细胞).
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