梦想在健康大脑和神经疾病中的新兴作用
Pasquale Molinaro1, Luca Sanguigno1, Antonella Casamassa2
1Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini, 5, 80131 Naples, Italy.
International journal of molecular sciences
|June 10, 2023
概括
下游调节元素对抗调节器 (DREAM) 蛋白质,当失调时,通过抑制神经保护基因,导致神经退行性疾病. 准DREAM为中枢神经系统疾病提供了潜在的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 下游调节元素对抗剂调节器 (DREAM) 是一种对Ca2+敏感的蛋白质,可以调节对Ca2+依赖的过程.
- 梦想通过梦想调节元件 (DRE) 影响基因表达,并调节蛋白质活性/局部化.
研究的目的:
- 审查了解DREAM失调及其在中枢神经系统 (CNS) 疾病中的作用方面的最新进展.
- 要突出DREAM依赖的表观遗传改造作为神经退行的一个机制.
主要方法:
- 文献综述总结了关于DREAM的当前研究.
- 分析DREAM在基因调节和蛋白质调节中的作用.
- 检查DREAM在病理状况中的参与.
主要成果:
- 梦的失调与中风,阿尔茨海默病,亨廷顿病,ALS和神经病痛有关.
- 梦想可以抑制关键的神经保护基因,如NCX3,BDNF,pro-dynorphin和c-fos.
- 梦想在各种中枢神经系统疾病中发挥着共同的有害作用.
结论:
- 梦想通过抑制神经保护基因转录,作为中枢神经系统疾病的常见有害因素.
- 针对DREAM是一个有前途的治疗途径,可以改善中枢神经系统疾病的症状和神经退行.
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