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血清进激素水平可能会区分非IPFILD与IPFILD

Nóra Melinda Tóth¹, Veronika Müller¹, Tamás Nagy¹

¹Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary.

International journal of molecular sciences

|June 10, 2023

概括

血清原原蛋白 (PGRN) 可能有助于区分间歇性肺部疾病 (ILD). 在非IPF的ILD患者中发现了PGRN水平的升高,特别是在HRCT扫描中发现异常间歇性肺炎 (UIP) 模式的患者中.

科学领域:

肺部病理学肺部病理学
生物标志物发现发现
诊断成像诊断成像诊断成像

背景情况:

诊断间歇性肺病 (ILD) 是复杂的.
血清progranulin (PGRN) 已与肝纤维化和皮肤肌炎相关的急性间歇性肺炎有关.
确定用于ILD诊断的可靠生物标志物至关重要.

研究的目的:

评估血清前列腺素 (PGRN) 在区分异常性肺纤维化 (IPF) 与其他ILDs中的实用性.
调查PGRN水平与ILD中的特定高分辨率计算机断层扫描 (HRCT) 模式之间的关联.

主要方法:

血清PGRN水平使用酶相关免疫吸收试验 (ELISA) 量化.
测量是在稳定的IPF (n=40),非IPFILD (n=48) 和健康对照 (n=17) 的患者中进行的.
分析了临床数据,肺功能测试和HRCT发现.

主要成果:

与健康对照组和IPF患者相比,非IPF ILD患者的血清PGRN水平显著更高 (p < 0.01).
与健康对照组相比,IPF患者的PGRN水平没有显著差异.
较高的PGRN水平与非常见的间歇性肺炎 (非UIP) HRCT模式相关,而正常水平与UIP模式相关.

结论:

血清PGRN水平升高可能作为非IPFILDs的生物标志物.
PGRN可以帮助区分IPF与其他ILD,特别是当放射学模式模糊时.
需要进一步的研究来证实PGRN在ILD诊断中的作用.

关键词:

差异诊断是一种差异诊断.异形性肺纤维化异形性肺纤维化间歇性肺病间歇性肺病益格拉努林是一种前列腺素.通常的间歇性肺炎.

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