COVID-19:多发性硬化症患者的病程,疫苗接种和免疫反应:系统性审查
Marcin Bazylewicz1, Monika Gudowska-Sawczuk2, Barbara Mroczko2,3
1Department of Neurology, Medical University of Bialystok, M. Skłodowskiej-Curie 24A St., 15-276 Bialystok, Poland.
International journal of molecular sciences
|June 10, 2023
概括
患有多发性硬化症 (MS) 的患者面临的COVID-19风险与一般人群相似,尽管某些因素如并发症和特定治疗增加了严重程度. 对感染和疫苗接种的免疫反应因疾病修饰疗法 (DMT) 而异.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19对多发性硬化症 (MS) 患者的影响,特别是那些接受疾病修饰疗法 (DMT) 或葡萄糖皮质激素的患者,最初是未知的.
- 了解SARS-CoV-2对MS复发和伪复发的影响至关重要.
研究的目的:
- 审查患有多发性硬化症 (PwMS) 患者COVID-19的风险,症状,病程和死亡率.
- 在PwMS中检查对COVID-19疫苗接种的免疫反应.
- 为了确定影响PwMS中COVID-19结果的因素.
主要方法:
- 在PubMed数据库上使用特定的搜索标准进行了文献搜索.
- 该审查综合了PwMS中COVID-19感染,接种疫苗和免疫反应的数据.
主要成果:
- 一般来说,PwMS与普通人群面临的COVID-19感染,住院,症状和死亡风险相似.
- 伴随性疾病,男性性别,更高的残疾和年龄较大与PwMS中COVID-19严重程度的增加有关.
- 抗CD20治疗可能会增加严重COVID-19结果的风险. 免疫对感染/疫苗接种的反应受到DMT的影响.
结论:
- 虽然PwMS与普通人群共享许多COVID-19风险,但某些因素需要特别注意.
- 在PwMS中,感染或接种疫苗后获得免疫的程度取决于他们的DMT.
- 需要进一步的研究来证实这些发现,并指导临床管理.
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