药物抗氧化剂的预期和意外影响
Irina Tyuryaeva1, Olga Lyublinskaya1
1Department of Intracellular Signaling and Transport, Institute of Cytology of the Russian Academy of Sciences, Tikhoretskii pr. 4, 194064 St. Petersburg, Russia.
International journal of molecular sciences
|June 10, 2023
概括
抗氧化剂如N-乙半氨酸,多和维生素C在体内表现出复杂的作用. 它们的细胞保护作用源于激活氧化还原通路,导致依赖于度和环境的双相反应.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗氧化剂如N-乙半氨酸,多和维生素C在研究和临床环境中广泛使用.
- 它们的体外抗氧化能力 (清除自由基) 并不总是转化为体内有效性.
- 抗氧化剂研究中的相互矛盾的结果需要更深入地了解它们的机制.
研究的目的:
- 审查和综合有关常见抗氧化剂生物活性的现有数据.
- 阐明它们的细胞保护作用背后的机制,特别是在体内.
- 解释抗氧化剂作用的可变性和上下文依赖性.
主要方法:
- 关于N-乙半氨酸,多和维生素C的研究文献综述.
- 对有关体外与体外抗氧化活性数据的分析.
- 检查氧化还原通路和霍尔梅西斯在抗氧化作用中的作用.
主要成果:
- 抗氧化剂的体内激素清除能力通常未得到证实,尽管体外有能力.
- 细胞保护与细胞氧化还原通路的激活有关,而不是抑制激素.
- 低度的抗氧化剂可以通过反氧活性化合物 (例如,H2O2,H2S) 刺激内源防御,而高度可能是有害的.
- 抗氧化剂的活性高度依赖于生物背景和应用方法.
结论:
- 抗氧化剂所观察到的双相性,热性和性作用解释了相互矛盾的研究结果.
- 了解这些上下文依赖的反应对于开发有效的抗氧化剂治疗策略至关重要.
- 需要考虑细胞氧化还原信号的细微方法,以获得最佳的抗氧化剂应用.
关键词:
对于 EGCG 的情况来说,这是一项非常重要的决定.这是一种N-乙囊氨酸.在NAC中,NAC是NAC的代表.这就是ROSOS ROS.抗氧化剂 抗氧化剂是一种抗氧化剂.亚甲酸盐是一种亚酸盐.库尔库明是一种黄素.聚醇是一种多醇.复星醇是一种复星醇.维生素C是维生素C的重要组成部分.更多相关视频
12:00Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
19.2K
11:06Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
2.0K
相关概念视频
01:27Effects of Chemicals: Overview
1.3K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.3K
01:30Combined Effects of Drugs: Antagonism
8.7K
The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
8.7K
01:27Combined Effects of Drugs: Synergism
4.1K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.1K
01:19Pharmacovigilance
914
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
914
01:54The Placebo Effect
6.2K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.2K
01:19Phase I Oxidative Reactions: Overview
308
Phase I biotransformation, or functionalization, is a crucial chemical process that converts drugs and other xenobiotics into more water-soluble forms, facilitating expulsion from the body. It involves oxidative, reductive, and hydrolytic reactions that add or unveil polar functional groups on lipophilic substrates. Key players in phase I reactions are the mixed-function oxidases. Situated in liver cell microsomes, these enzymes predominantly carry out drug metabolism. They require molecular...
308