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Updated: Jul 27, 2025

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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Published on: March 20, 2018

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人类APOBEC3A驱动的肝细胞癌在活体中需要DNA除染

Jordan A Naumann1,2, Prokopios P Argyris1,2,3,4, Michael A Carpenter5,6

  • 1Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

International journal of molecular sciences
|June 10, 2023
PubMed
概括

DNA 脱氨酶 APOBEC3A 通过改变DNA而不是RNA来驱动瘤的形成. 它的催化活性对于这种促进癌症的机制至关重要,使其成为恶性瘤的关键驱动因素.

关键词:
在 APOBEC3A 中,APOBEC3A通过DNA去胺处理.基因突变是一种DNA突变.编辑RNA的RNA编辑癌症发生的原因是致癌.肝细胞癌是肝细胞癌.分子机制的分子机制.瘤发生的起源

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