高密度胆固醇 (HDL) 亚类和氧酶-1活性分布在ST段升高急性心肌梗塞患者中
Saska Djekic1, Jelena Vekic2, Aleksandra Zeljkovic2
1Department of Laboratory Diagnostics Public Health Institution "Health Center", 74000 Doboj, Bosnia and Herzegovina.
International journal of molecular sciences
|June 10, 2023
概括
在心脏病发作患者中,氧化应激和小而密集的LDL增加,损害了小的HDL颗粒中的抗氧化功能,并改变了类氧化酶-1活性.
科学领域:
- 心血管医学 心血管医学
- 脂质代谢 脂质代谢是什么
- 生物化学 生物化学
背景情况:
- 氧化应激,炎症和小而密集的低密度脂蛋白 (sdLDL) 都与心血管疾病有关.
- 高密度脂蛋白 (HDL) 在逆胆固醇运输中起着至关重要的作用,并具有抗氧化特性.
- 偏氧酶-1 (PON1) 是一种与高脂相关的酶,具有保护性功能,可以防止LDL的氧化.
研究的目的:
- 研究氧化应激,炎症和sdLDL对HDL亚类和PON1活动分布在ST段升高急性心肌梗塞 (STEMI) 患者的影响.
- 在STEMI患者和健康对照者之间比较HDL子类和PON1活动分布.
主要方法:
- 多中心研究涉及69名STEMI患者和67名健康对照.
- 使用聚烯胺梯度凝电泳分离脂蛋白子类.
- 通过密度计扫描量化HDL子类和sdLDL比例的量化.
- 在HDL子类内评估PON1活动分布,使用zymogram方法.
主要成果:
- 与对照组相比,STEMI患者的HDL2a和HDL3a比例明显较低,HDL3b和HDL3c比例较高.
- 在STEMI患者中,在HDL3b中发现了较低比例的PON1活性,而HDL2显示了较高的PON1活性.
- 在HDL3a中观察到sdLDL和PON1活性之间的积极关联,以及在STEMI患者的HDL2b中发现malondialdehyde (MDA) 和PON1活性之间的积极关联.
结论:
- 增加的氧化应激和sdLDL与STEMI中小HDL3颗粒中抗氧化功能受损有关.
- 在HDL子类内改变PON1活动分布有助于STEMI的病理生理学.
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