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血友病和脆弱性骨折:从致病源到多学科方法
Angelo Alito1, Federica Bellone2, Simona Portaro3
1Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, 98100 Messina, Italy.
International journal of molecular sciences
|June 10, 2023
概括
血友病患者 (PWH) 由于多因素骨损失而面临脆弱性骨折的增加. 多学科管理和量身定制的康复对于改善生活质量和预防并发症至关重要.
科学领域:
- 血液学 血液学 血液学
- 整形外科 整形外科 整形外科
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 血友病A (HA) 和血友病B (HB) 是遗传性出血障碍,原因是凝血因子VIII (FVIII) 和IX (FIX) 的缺陷.
- 血友病 (PWH) 患者的预期寿命增加导致并发病的增加,特别是脆弱性骨折.
- 了解PWH中骨折管理的独特挑战至关重要.
研究的目的:
- 审查有关血友病患者 (PWH) 脆弱性骨折的发病和多学科管理的文献.
- 综合有关骨质损失机制和PWH治疗策略的当前知识.
主要方法:
- 在PubMed,Scopus和Cochrane图书馆进行了全面的文献搜索.
- 包括原始研究文章,元分析和科学评论,重点关注PWH的脆弱性骨折.
主要成果:
- 在PWH中,骨损失是多因素的,包括关节出血,体力活动减少,营养缺乏 (例如维生素D) 和FVIII/FIX缺乏.
- 治疗选择包括药理学药物 (抗吸收剂,合成体,双作用药物) 和当保守管理失败时的手术干预.
- 康复对于恢复功能和维持运动能力至关重要.
结论:
- 在PWH中有效的骨折管理需要采用多学科方法,整合药理治疗,手术选择和量身定制的康复.
- 优化护理途径对于提高生活质量和减轻PWH的长期并发症至关重要.
- 需要进一步的临床试验来完善PWH的骨折管理策略.
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