与职业接触和马拉相关的生物标志物的网络分析
Marcus Vinicius C Santos1, Arthur S Feltrin2, Isabele C Costa-Amaral1
1Studies Center of Worker's Health and Human Ecology (CESTEH), Sergio Arouca National School of Public Health (ENSP), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21041-210, RJ, Brazil.
International journal of molecular sciences
|June 10, 2023
概括
网络医学工具揭示了和马拉暴露如何影响人类细胞. 确定了像IL-8和HRAS这样的关键枢纽基因,为复杂的疾病机制提供了见解.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 网络医学 网络医学
背景情况:
- 复杂的疾病涉及多个基因,蛋白质和途径.
- 网络医学提供了一种系统的方法来探索分子复杂性和识别疾病模块.
- 了解环境化学物质暴露对于预防疾病至关重要.
研究的目的:
- 通过网络医学研究和马拉暴露的分子效应.
- 为了确定关键的基因和受这些化学物质暴露影响的途径.
- 了解环境化学物质影响人类细胞功能的机制.
主要方法:
- 在暴露于和马拉后选择差异表达的基因.
- 使用GeneMANIA和STRING构建蛋白质与蛋白质相互作用网络.
- 使用MCODE,BiNGO和CentiScaPe对网络进行拓分析,以确定枢纽基因.
主要成果:
- 构建了一个含有114个基因和2415个相互作用的基因网络,揭示了五个子网络.
- 基因网络中的关键枢纽基因包括IL-8,KLF6,KLF4,JUN,SERTAD1和MT1H.
- 一个由67个蛋白质和134个相互作用组成的马拉网络将HRAS和STAT3确定为中心节点.
结论:
- 网络医学有效地阐明了化学暴露的分子复杂性.
- 已识别的枢纽基因在对和马拉的生物反应中起着核心作用.
- 这种方法提高了对化学毒性机制和疾病预防策略的理解.
更多相关视频
08:14Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
Published on: April 28, 2023
411
09:33Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
Published on: December 23, 2022
2.3K
相关概念视频
NMR Spectroscopy of Benzene Derivatives
8.5K
Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling...
8.5K
Types of Toxins
1.8K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.8K
