多功能蛋白质Syntenin-1:对外体生物发生,细胞功能和瘤进展的调节者
Kwang-Min Lee1,2, Eun-Chan Seo1,2, Jeong-Hyung Lee3
1Division of Life Science, College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
International journal of molecular sciences
|June 10, 2023
概括
合成蛋白-1 调节了外体细胞的流通和细胞间的通信. 针对这种机制提供了潜在的新策略来治疗由syntenin-1和microRNA相互作用驱动的癌症.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 癌症研究 癌症研究
背景情况:
- 合成作为PDZ域的支架蛋白,影响信号通路和细胞功能.
- 合成因-1被认为是一种参与癌症进展,转移和血管生成的瘤基因.
- 合成-1对外体的产生和释放至关重要,外体是细胞间通信的关键媒介.
研究的目的:
- 审查合成蛋白-1在调节外体贩运中的作用.
- 探索syntenin-1,外体和与癌症相关的信号通路之间的联系.
- 突出潜在的治疗策略,针对癌症中的合成因-1介导的外体调节.
主要方法:
- 关于syntenin-1研究的文献综述,外体生物学和癌症.
- 对syntenin-1与诸如syndecan和ALIX之类的结合伙伴的相互作用进行分析.
- 检查microRNA在调节syntenin-1和外体荷载中的作用.
主要成果:
- 辛宁-1通过与辛德肯和ALIX的相互作用促进了外体细胞贩运.
- 受到syntenin-1影响的微RNA外体转移可以调节与癌症相关的基因表达.
- 合成蛋白-1参与外体调节是一个新的治疗点.
结论:
- 合成蛋白-1 在外体介导的细胞间通信中起着关键作用.
- 合成蛋白-1-外因子-微RNA轴是癌症发展和进展的重要因素.
- 针对syntenin-1在外体调节中的功能,为癌症治疗提供了一个有前途的途径.
相关概念视频
Role of Septins
1.8K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
1.8K
Overview of Exosomes
2.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K
The Nucleolus
8.9K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.9K
Pleiotropy
40.7K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.7K
Destabilization of Microtubules
2.8K
The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
2.8K
The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K


