由电压成像揭示的迷幻诱导的震动行为的皮层相关性
Tobias Buchborn1,2, Taylor Lyons1,3, Chenchen Song1
1Laboratory for Neuronal Circuit Dynamics, Imperial College London, London W12 0NN, UK.
International journal of molecular sciences
|June 10, 2023
概括
迷幻药物会触发小鼠的震动行为,与血清素2A受体有关. 这项研究揭示了在这种行为期间金字塔神经元中特定的大脑活动模式,为迷幻效应提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 计算生物学 计算生物学
背景情况:
- 哺乳动物的震动行为是迷幻药物效应的关键指标.
- 据假设,血清素2A受体通过皮质金字塔细胞调解这种行为.
- 直接的体内证据将金字塔细胞与迷幻诱导的震动联系在一起是有限的.
研究的目的:
- 用体内成像研究二三层金字塔神经元在幻觉诱导的震动行为中的作用.
- 为了将特定的神经活动模式与可观察到的震动行为相关联.
- 建立跨哺乳动物迷幻效应和细胞类型特定的大脑动态之间的联系.
主要方法:
- 在清醒的小鼠中利用了细胞类型特定的电压成像.
- 在层2/3的金字塔神经元中表达了VSFP蝶1.2电压指示器.
- 同时记录皮质血液动力学和神经电压活动在震动行为.
主要成果:
- 震动行为之前有高频振荡,并与运动皮层中低频振荡相吻合.
- 观察到的神经振荡的光谱反映了摇行为的节奏.
- 证实二/三层金字塔细胞活动和血液动力学与震动相关.
结论:
- 鉴定出一种与色胺-2A受体介导的震动行为相关的明显皮质活动特征.
- 在细胞水平上研究迷幻效应的新方法论方法.
- 提供了支持金字塔细胞参与迷幻药物作用的体内证据.
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