针对抗抑郁药和抗精神病药物药理疗法的新型潜在分子标
Yuriy M Kositsyn1,2,3,4, Murilo S de Abreu5, Tatiana O Kolesnikova1,2,3,6
1Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg 197341, Russia.
International journal of molecular sciences
|June 10, 2023
概括
对抑郁症和精神分裂症需要新的药物标,因为目前的治疗方法效率低下. 本综述涵盖了开发新抗抑郁药和抗精神病药物的进展,工具和挑战.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- 抑郁症和精神分裂症是普遍存在的,使人衰弱的神经精神疾病.
- 目前的抗抑郁药和抗精神病药物疗法存在局限性,包括效率低下,副作用和患者不合格.
研究的目的:
- 讨论转化方面的进展,研究工具和在神经精神疾病中发现创新药物的方法.
- 提供现有的抗抑郁药和抗精神病药的概述.
- 概述抑郁症和精神分裂症治疗的潜在新型分子标.
主要方法:
- 关于当前药物治疗的综合文献综述.
- 对翻译挑战和研究缺口的分析.
- 识别和评估潜在的新型分子标.
主要成果:
- 目前对抑郁症和精神分裂症的治疗方法通常在临床上是无效的,并带来了重大挑战.
- 已经确定了几种有希望的新分子标,用于药物开发.
- 在现场仍然存在重大翻译挑战和未解决的问题.
结论:
- 对于新的药物标和改善抑郁症和精神分裂症的治疗策略,有极大的需求.
- 进一步的综合性,跨学科研究对于推进抗抑郁药物和抗精神病药物开发至关重要.
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