牛皮的蛋白质和代谢变化 临床前和临床方面
Adrianna Radulska1, Iwona Pelikant-Małecka1, Kamila Jendernalik1
1Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland.
International journal of molecular sciences
|June 10, 2023
概括
蛋白质学和代谢学为了解牛皮和牛皮性关节炎提供了新的方法. 这些研究有助于找到生物标志物和药物点,以更好地治疗患者.
科学领域:
- 免疫皮肤学 免疫皮肤学
- 翻译医学是一种翻译医学.
- 系统生物学 系统生物学
背景情况:
- 牛皮 (Ps) 和牛皮性关节炎 (PsA) 是复杂的免疫媒介炎症疾病.
- 诊断和治疗的挑战来自重叠的自身炎症/自身免疫性疾病和缺乏生物标志物.
- 牛皮亚型的异质性使个性化医疗方法复杂化.
研究的目的:
- 审查蛋白质学和代谢学在牛皮和牛皮性关节炎研究中的应用.
- 突出这些"omics"策略在研究和临床环境中的有用性.
- 确定生物药物开发的关键生物标志物和治疗点.
主要方法:
- 使用蛋白质组学和代谢组学研究的综合文献综述.
- 包括来自体内动物模型,学术研究和临床试验的数据.
- 对已识别的蛋白质和小分子进行分析,这些蛋白质和小分子与疾病发病相关.
主要成果:
- 蛋白质学和代谢学已经确定了许多涉及Ps和PsA的蛋白质和代谢物.
- 这些"omics"方法揭示了疾病诊断和进展的潜在生物标志物.
- 在发现生物疗法新标的过程中做出重大贡献.
结论:
- 蛋白质组学和代谢组学是解开Ps和PsA病变的强大工具.
- 这些策略对于生物标志物发现和个性化治疗策略的开发至关重要.
- 这些发现支持针对免疫介导性皮肤和关节疾病的向生物疗法的发展.
相关概念视频
Proteomics
7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.5K
Changes in Skin Color: Clinical Perspectives
2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K


