在严重喘中切换生物疗法
Giulia Scioscia1, Santi Nolasco2,3, Raffaele Campisi2
1Department of Medical and Surgical Sciences, University of Foggia, 71121 Foggia, Italy.
International journal of molecular sciences
|June 10, 2023
概括
切换严重喘的生物疗法可能是有效的,特别是对于具有高氨基酸细胞数量的患者. 选择治疗时应考虑患者病史,生物标志物如血中乙氨基酸,以及伴随性疾病如鼻多重症.
科学领域:
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在意大利,三类单克隆抗体 (抗IgE,抗IL-5/IL-5Rα,抗IL-4Rα) 已被批准用于治疗严重喘.
- 随机对照试验和实践研究评估这些生物制剂的疗效和预测因素.
- 切换生物药物是对反应不佳的患者的一种策略.
研究的目的:
- 审查当前关于在严重喘中切换生物疗法的知识.
- 为了确定转换生物药物后治疗反应或失败的预测因素.
- 总结关于生物切换的现实世界的证据.
主要方法:
- 现实生活研究和随机对照试验对严重喘中的生物切换进行了审查.
- 分析与治疗反应或失败相关的患者特征.
- 对不同单克隆抗体的疗效预测指标的综合数据.
主要成果:
- 大多数切换数据来源于现实生活研究.
- 奥马利祖马布经常是最初的生物疗法.
- 由于控制不佳而转换的患者往往具有较高的血中乙氨基酸基数和恶化率,并且依赖于口服皮质类固醇 (OCS).
结论:
- 切换生物药物是严重喘患者的可行选择,反应不足.
- 患者的临床病史,生物标志物 (血液中乙酸盐,FeNO) 和并发症 (鼻多重症) 可以指导治疗选择.
- 需要进一步的研究来描述患者的个人资料,因为重叠的指示,他们可以从转换到不同的单克隆抗体中获益.
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