自然产品的COVID-19治疗潜力自然产品的治疗潜力
Zhaoxuan Low1, Rafidah Lani2, Vunjia Tiong1
1Tropical Infectious Diseases Research & Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur 50603, Malaysia.
International journal of molecular sciences
|June 10, 2023
概括
自然产品为COVID-19治疗提供了成本效益和可访问的替代方案,特别是在低收入国家. 本综述探讨了它们的抗病毒机制和作为针对SARS-CoV-2的治疗候选者的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 传染性疾病 传染性疾病
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 仍然是一个重大的全球健康威胁,导致严重疾病和死亡.
- 在低收入国家,获得疫苗和抗病毒药物等先进的COVID-19治疗方法是有限的.
- 包括中国传统医药在内的天然产品,为COVID-19治疗提供了一个有前途的替代方案.
研究的目的:
- 审查天然产品的抗SARS-CoV-2机制.
- 评估天然产品对SARS-CoV-2的药理学概况和功效.
- 讨论COVID-19干预中天然产品的应用策略.
主要方法:
- 对天然产品及其对SARS-CoV-2的抗病毒活性研究的系统文献综述.
- 分析报告的作用机制,包括病毒进入抑制,复制干扰和免疫调节.
- 评估可用的药理动力学和药理动力学数据.
主要成果:
- 许多天然产品及其衍生物在体外和体内表现出显著的抗病毒活性,对抗SARS-CoV-2.
- 已识别的机制包括病毒蛋白酶,聚合酶和宿主细胞受体的抑制.
- 传统中医药和特定的植物提取物显示出强大的治疗潜力.
结论:
- 自然产品是开发新型COVID-19治疗方法的可行,负担得起和可访问的资源.
- 进一步研究它们的机制和临床应用是有必要的,以对抗正在进行的流行病.
- 利用天然产品可以改善传染病管理中的全球健康公平.
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