肥胖和卡路里限制对癌症发展的影响
Ekaterina Sergeeva1, Tatiana Ruksha1, Yulia Fefelova1
1Department of Pathological Physiology, Krasnoyarsk State Medical University, No. 1 P. Zheleznyaka Str., 660022 Krasnoyarsk, Russia.
International journal of molecular sciences
|June 10, 2023
概括
肥胖通过代谢变化增加癌症风险. 卡路里限制影响关键的细胞通路,可能抑制癌症生长,提高治疗效率.
科学领域:
- 在瘤学瘤学.
- 代谢综合征是代谢综合征的一种.
- 癌症生物学 癌症生物学
背景情况:
- 肥胖是各种恶性瘤的重要全球风险因素.
- 肥胖的代谢变化,包括荷尔蒙变化,炎症和缺氧,促进癌症的发展.
- 卡路里限制 (CR) 是一种饮食干预,在多种疾病中具有潜在的健康益处.
研究的目的:
- 审查肥胖和癌症发展之间的联系.
- 阐明卡路里限制影响癌症发生的机制.
- 强调需要对CR进行进一步的研究,以便在癌症预防和治疗中进行临床应用.
主要方法:
- 关于卡路里限制和癌症的体外和体内研究的文献综述.
- 分析受卡路里限制影响的代谢和细胞信号通路.
- 检查CR对癌细胞增殖,迁移,存活和亡的影响.
主要成果:
- 卡路里限制调节关键信号通路,包括AMP激活蛋白激酶 (AMPK),哺乳动物的目标拉巴素 (mTOR),以及胰岛素/胰岛素类生长因子1 (IGF1).
- 禁食和卡路里限制可以调节诸如基激活蛋白激酶 (MAPK),p53和JAK-STAT等途径.
- 通过卡路里限制对这些途径的调节导致癌细胞增殖和存活率降低,亡增加,化学疗法效果增强.
结论:
- 卡路里限制在减轻与肥胖相关的癌症风险方面具有显著的潜力.
- 了解CR对细胞信号通路的影响对于开发新型癌症疗法至关重要.
- 需要进一步的临床研究来将卡路里限制策略纳入癌症护理.
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