相关实验视频

Updated: Jul 27, 2025

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
08:57

Aip1p Dynamics Are Altered by the R256H Mutation in Actin

Published on: July 30, 2014

8.0K

滑动肌肉-阿尔法动因R149C致病变体降低调节细胞矩阵粘附处的整合素招募并降低细胞收缩性

Krishna R Ojha1, Hyoseon Kim2, Samuel Padgham1

  • 1Department of Medical Physiology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.

International journal of molecular sciences
|June 10, 2023
PubMed
概括

在ACTA2的致病变体损害大动脉光滑肌细胞收缩,导致胸前大动脉动脉瘤. 这项研究显示,突变细胞中改变了actin异型表达和减少了整合素招募,从而降低了大动脉收缩性.

关键词:
在Acta2R149C/+小鼠中使用.这就是Actin Actin.整合物是一种整合物.血管光滑肌肉细胞的细胞.

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Actin Polymerization and Cell Motility

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Integrins01:10

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Actin is a highly conserved cytoskeletal protein found abundantly in eukaryotic cells. It constitutes 10% weight of the total cellular protein in muscle cells, while in non-muscle cells, it is lower and makes up around 1–5 percent of the total cell protein. Actin found in the unicellular amoebae and complex multicellular animals is around 80% similar, demonstrating their conservation over a billion years of evolution.  Actin coding genes are conserved within species and across...
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