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查和分析可能与PDGFRα结合的药物:一个分子建模研究

Matteo Mozzicafreddo1, Devis Benfaremo1,2, Chiara Paolini1

  • 1Department of Clinical and Molecular Sciences, Marche Polytechnic University, 60126 Ancona, Italy.

International journal of molecular sciences
|June 10, 2023
PubMed
概括

研究人员选了7200种化合物,以发现新的血小板衍生生长因子受体 (PDGFR) 抑制剂. 一些药物和天然化合物,包括巴菲蒂尼布和黄素,显示出高亲和力,为新的PDGFR向疗法提供了潜力.

关键词:
在PDGF受体 (PDGFR) 中.分子对接的分子对接.分子动力学 (MD) 是指分子动力学.定量结构活动关系 (QSAR)基于结构的药物设计 (SBDD)系统性硬化症 (SSc) 是一种疾病.

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