米瑞:通过调节炎症和信号转导通路,对其抗癌潜力的显著强调
Arshad Husain Rahmani1, Ahmad Almatroudi1, Khaled S Allemailem1
1Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.
International journal of molecular sciences
|June 10, 2023
概括
植物性抗氧化剂Myricetin通过减少炎症和诱导癌细胞死亡,显示出作为天然癌症治疗的前景. 进一步研究myricetin的研究.
科学领域:
- 自然产品化学 自然产品化学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 癌症对全球健康构成重大挑战,目前的治疗方法造成严重的不良影响.
- 对于具有提高疗效和降低毒性的新型抗癌药物有着迫切的需求.
- 自然存在的化合物,如myricetin,正在探索它们在癌症管理中的治疗潜力.
研究的目的:
- 审查myricetin在癌症管理中的作用.
- 探索myricetin的作用机制,包括其抗氧化和抗炎性质.
- 讨论其与传统化疗的潜在协同效应以及改善其生物可用性的策略.
主要方法:
- 对瑞和癌症的体内和体外研究的文献综述.
- 分析myricetin对细胞信号通路,血管新生,炎症,细胞循环和细胞亡的影响.
- 检查myricetin与现有的抗癌药物的相互作用.
主要成果:
- 米瑞素表现出抗氧化,抗炎和肝脏保护作用.
- 它通过调节血管生成,炎症 (抑制iNOS和Cox-2),细胞循环停止和诱导亡来证明抗癌潜力.
- 米瑞可以增强传统化疗剂的疗效.
结论:
- 瑞是一种有前途的天然化合物,用于癌症管理,因为它具有多方面的作用机制.
- 需要进一步的研究来优化其传递,并探索用于增强抗癌活性的新衍生物.
- 临床试验和纳米配方的开发对于将myricetin的潜力转化为有效的癌症疗法至关重要.
更多相关视频
09:03Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
411
13:18Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
Published on: March 3, 2023
1.3K
相关概念视频
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:54Canonical Wnt Signaling Pathway
8.8K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.8K
01:20The JAK-STAT Signaling Pathway
9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.0K
01:41Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
02:38Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K