具有不同分子重量的氨酸可以以不同的方式影响肠道微生物群和重症监护综合征后小鼠的病原遗传进展
Lu Li1, Yuanyuan Jiang1, Qianqian Zhu1
1Biopharmaceutical Lab., College of Life Science, Northeast Agricultural University, Harbin 150030, China.
International journal of molecular sciences
|June 10, 2023
概括
氨酸 (HA) 显示出治疗重症监护后综合征 (PICS) 的潜力. 高分子量HA改善了小鼠的生存率,而低分子量HA具有多种影响,影响肠道微生物群. 需要进一步的研究.
科学领域:
- 生物医学科学 生物医学科学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 后重症监护综合征 (PICS) 是ICU幸存者的重大健康问题,有效治疗方法有限.
- 随着ICU生存率的上升,需要开发治疗策略来缓解PICS症状.
- 氨 (HA),一种天然存在的多糖,正在研究其治疗潜力.
研究的目的:
- 评估不同分子量氨酸 (HA) 在治疗PICS.小鼠模型中的疗效.
- 研究HA治疗对肠道微生物群组成的影响及其与PICS的相关性.
- 评估在HA给药后PICS小鼠的病理和生理变化.
主要方法:
- 建立了一个PICS小鼠模型,使用结和穿孔 (CLP).
- 小鼠接受了高分子量HA (1600 kDa) 或oligo-HA (3 kDa) 的治疗.
- 监测了生存率,病理变化和肠道微生物群组成 (通过16S rRNA测序).
主要成果:
- 高分子量和低分子量HA都增加了PICS小鼠的生存率.
- 1600kDa-HA显示了短期PICS缓解,而3kDa-HA降低了早期生存率.
- HA治疗逆转了PICS诱导的肠道微生物群失调,减少了炎症,并改善了肠道结构. 3 kDa-HA 特别增加了益生菌和减少了致病细菌.
结论:
- 氨 (HA) 对PICS来说是一个有前途的治疗途径,分子重量显著影响结果.
- 1600kDa-HA在PICS小鼠中显示出保护作用,表明其作为治疗剂的潜力.
- 在使用HA用于PICS治疗时,仔细考虑时间和分子量至关重要,特别是对于3kDa-HA.
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